ABSTRACT
Objective: To observe MRI features of breast invasive lobular carcinoma (ILC), and to analyze the relationship of functional MRI parameters and Ki-67 index. Methods: Data of 184 patients with breast cancer confirmed pathologically were retrospectively analyzed, including 52 cases of ILC (ILC group) and 132 cases of invasive ductal carcinoma (IDC). All patients received preoperative breast MRI. MRI morphological manifestations and functional parameters were compared between 2 groups, and the relationships of functional MRI parameters and Ki-67 index of ILC were analyzed. Results: Compared with those in IDC group, Ki-67 indexes in ILC group were lower (t=-3.50, P<0.01), while non-mass-like enhancement was more common (χ2=48.74, P<0.01), ADC and time to peak (TTP) value were both higher (t=2.48, 2.98, both P<0.05). Ki-67 index of ILC was negatively correlated with ADC value (r=-0.67, P<0.01) and positively correlated with early enhancement rate (r=0.52, P<0.01). Conclusion: MRI findings of breast ILC had certain characteristics, providing references for preoperative diagnosis of ILC and prognosis assessment.